Maguire E A
Wellcome Department of Cognitive Neurology, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK.
Rev Neurol (Paris). 2001 Sep;157(8-9 Pt 1):791-4.
The hippocampus has long been implicated in mnemonic function, although its precise role is still keenly debated. Neuroimaging techniques such as positron emission tomography, functional magnetic resonance imaging and structural MRI, provide the means to examine in vivo the dynamic nature of human memory. Here, I briefly discuss how neuroimaging has investigated complex real-world memories of the kind typically reported lost by patients in the clinical context. A role, paralleling that documented in animals, for the right hippocampus in navigation is clearly apparent from functional and structural neuroimaging findings. In contrast, the left hippocampus is more responsive to memories for events that occur in a specific time and place (episodic memory) that characterise one's personal, or autobiographical, memory store from throughout the lifetime. Neuroimaging is well-placed to extend our understanding of the differential contributions the left and right hippocampi make to aspects of memory and how they interface to produce a unitary representation of the past.
长期以来，海马体一直被认为与记忆功能有关，尽管其确切作用仍存在激烈争论。正电子发射断层扫描、功能磁共振成像和结构磁共振成像等神经成像技术，为在体内研究人类记忆的动态本质提供了手段。在此，我简要讨论神经成像如何研究临床上患者通常报告丧失的那种复杂的现实世界记忆。从功能和结构神经成像结果中可以清楚地看出，右海马体在导航中的作用与在动物身上记录的作用相似。相比之下，左海马体对发生在特定时间和地点的事件（情景记忆）的记忆反应更强，这些事件构成了一个人一生中个人或自传式记忆库的特征。神经成像有助于扩展我们对左右海马体在记忆方面的不同贡献以及它们如何相互作用以产生过去的统一表征的理解。
