Hoffmann P R, Darnell J E
J Virol. 1975 Apr;15(4):806-11. doi: 10.1128/JVI.15.4.806-811.1975.
In adenovirus type 2-transformed rat embryo cells there is a threefold greater incorporation of [3-H]uridine into virus-specific RNA early in S phase than in late S or G2. This heightened accumulation of labeled RNA is true for both nuclear and cytoplasmic virus-specific labeling. Inhibition of DNA synthesis decreases the virus-specific RNA labeling, whereas reversal of inhibition again allows the elevated level of virus-specific RNA labeling.
在2型腺病毒转化的大鼠胚胎细胞中,在S期早期,[3-H]尿苷掺入病毒特异性RNA的量比在S期晚期或G2期多三倍。这种标记RNA的积累增加在核内和胞质病毒特异性标记中均如此。DNA合成的抑制降低了病毒特异性RNA标记,而抑制的解除再次使病毒特异性RNA标记水平升高。