Franciosi M, Pellegrini F, De Berardis G, Belfiglio M, Cavaliere D, Di Nardo B, Greenfield S, Kaplan S H, Sacco M, Tognoni G, Valentini M, Nicolucci A
Department of Clinical Pharmacology and Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, S. Maria Imbaro, Italy.
Diabetes Care. 2001 Nov;24(11):1870-7. doi: 10.2337/diacare.24.11.1870.
The role of self-monitoring of blood glucose (SMBG) in type 2 diabetes is still a matter of debate. In the framework of a nationwide outcomes research program, we investigated the frequency of SMBG and its association with metabolic control and quality of life (QoL).
The study involved 3,567 patients with type 2 diabetes who were recruited by 101 outpatient diabetes clinics and 103 general practitioners. Patients completed a questionnaire investigating SMBG practice and QoL (diabetes-related stress, diabetes health distress, diabetes-related worries, and Centers for Epidemiologic Studies-Depression scale).
Data on SMBG were available for 2,855 subjects (80% of the entire study population). Overall, 471 patients (17%) stated that they tested their blood glucose levels at home > or =1 time per day, 899 patients (31%) tested their blood glucose levels > or =1 time per week, and 414 patients (14%) tested their blood glucose levels <1 time per week, whereas 1,071 patients (38%) stated that they never practiced SMBG. A higher frequency of SMBG was associated with better metabolic control among subjects who were able to adjust insulin doses, whereas no relationship was found in all other patients, irrespective of the kind of treatment. Multivariate analyses showed that an SMBG frequency > or =1 time per day was significantly related to higher levels of distress, worries, and depressive symptoms in non-insulin-treated patients.
Our findings suggest that SMBG can have an important role in improving metabolic control if it is an integral part of a wider educational strategy devoted to the promotion of patient autonomy. In patients not treated with insulin, self-monitoring is associated with higher HbA(1c) levels and psychological burden. Our data do not support the extension of SMBG to this group.
血糖自我监测(SMBG)在2型糖尿病中的作用仍存在争议。在一项全国性结局研究项目的框架内,我们调查了SMBG的频率及其与代谢控制和生活质量(QoL)的关联。
该研究纳入了由101家门诊糖尿病诊所和103名全科医生招募的3567例2型糖尿病患者。患者完成了一份关于SMBG实践和QoL的问卷(糖尿病相关压力、糖尿病健康困扰、糖尿病相关担忧以及流行病学研究中心抑郁量表)。
2855名受试者(占整个研究人群的80%)有SMBG数据。总体而言,471例患者(17%)表示他们在家中每天检测血糖水平≥1次,899例患者(31%)每周检测血糖水平≥1次,414例患者(14%)每周检测血糖水平<1次,而1071例患者(38%)表示他们从未进行过SMBG。在能够调整胰岛素剂量的受试者中,较高频率的SMBG与更好的代谢控制相关,而在所有其他患者中,无论采用何种治疗方式,均未发现相关性。多变量分析显示,在未接受胰岛素治疗的患者中,SMBG频率≥每天1次与更高水平的困扰、担忧和抑郁症状显著相关。
我们的研究结果表明,如果SMBG是致力于促进患者自主性的更广泛教育策略的一个组成部分,那么它在改善代谢控制方面可以发挥重要作用。在未接受胰岛素治疗的患者中,自我监测与更高的糖化血红蛋白(HbA1c)水平和心理负担相关。我们的数据不支持将SMBG扩展至该组患者。