Moore M C, Davis S N, Mann S L, Cherrington A D
Department of Molecular Physiology, Diabetes Research and Training Center, Vanderbilt University, Nashville, Tennessee 37232-0615, USA.
Diabetes Care. 2001 Nov;24(11):1882-7. doi: 10.2337/diacare.24.11.1882.
In normal adults, a small (catalytic) dose of fructose administered with glucose decreases the glycemic response to a glucose load, especially in those with the poorest glucose tolerance. We hypothesized that an acute catalytic dose of fructose would also improve glucose tolerance in individuals with type 2 diabetes.
Five adults with type 2 diabetes underwent an oral glucose tolerance test (OGTT) on two separate occasions, at least 1 week apart. Each OGTT consisted of 75 g glucose with or without the addition of 7.5 g fructose (OGTT + F or OGTT - F), in random order. Arterialized blood samples were collected from a heated dorsal hand vein twice before ingestion of the carbohydrate and every 15 min for 3 h afterward.
The area under the curve (AUC) of the plasma glucose response was reduced by fructose administration in all subjects; the mean AUC during the OGTT + F was 14% less than that during the OGTT - F (P < 0.05). The insulin AUC was decreased 21% with fructose administration (P = 0.2). Plasma glucagon concentrations declined similarly during OGTT - F and OGTT + F. The incremental AUC of the blood lactate response during the OGTT - F was approximately 50% of that observed during the OGTT + F (P < 0.05). Neither nonesterified fatty acid nor triglyceride concentrations differed between the two OGTTs.
Low-dose fructose improves the glycemic response to an oral glucose load in adults with type 2 diabetes, and this effect is not a result of stimulation of insulin secretion.
在正常成年人中，小剂量（催化剂量）的果糖与葡萄糖一起给予时，可降低对葡萄糖负荷的血糖反应，尤其是在葡萄糖耐量最差的人群中。我们假设，急性催化剂量的果糖也会改善2型糖尿病患者的葡萄糖耐量。
5名2型糖尿病成年人在两个不同的时间点进行口服葡萄糖耐量试验（OGTT），间隔至少1周。每次OGTT包含75 g葡萄糖，随机顺序添加或不添加7.5 g果糖（OGTT + F或OGTT - F）。在摄入碳水化合物之前，从加热的手背静脉采集两次动脉化血样，之后每15分钟采集一次，共采集3小时。
所有受试者中，果糖给药均降低了血浆葡萄糖反应的曲线下面积（AUC）；OGTT + F期间的平均AUC比OGTT - F期间低14%（P < 0.05）。果糖给药使胰岛素AUC降低了21%（P = 0.2）。OGTT - F和OGTT + F期间血浆胰高血糖素浓度的下降情况相似。OGTT - F期间血乳酸反应的增量AUC约为OGTT + F期间观察到的50%（P < 0.05）。两次OGTT之间非酯化脂肪酸和甘油三酯浓度均无差异。
低剂量果糖可改善2型糖尿病成年人对口服葡萄糖负荷的血糖反应，且这种作用并非胰岛素分泌受刺激的结果。
