Glaser P, Frangeul L, Buchrieser C, Rusniok C, Amend A, Baquero F, Berche P, Bloecker H, Brandt P, Chakraborty T, Charbit A, Chetouani F, Couvé E, de Daruvar A, Dehoux P, Domann E, Domínguez-Bernal G, Duchaud E, Durant L, Dussurget O, Entian K D, Fsihi H, García-del Portillo F, Garrido P, Gautier L, Goebel W, Gómez-López N, Hain T, Hauf J, Jackson D, Jones L M, Kaerst U, Kreft J, Kuhn M, Kunst F, Kurapkat G, Madueno E, Maitournam A, Vicente J M, Ng E, Nedjari H, Nordsiek G, Novella S, de Pablos B, Pérez-Diaz J C, Purcell R, Remmel B, Rose M, Schlueter T, Simoes N, Tierrez A, Vázquez-Boland J A, Voss H, Wehland J, Cossart P
Génomique des Microorganismes Pathogènes, Unité des Interactions Bactéries-Cellules, Service d'Informatique Scientifique, Institut Pasteur, 25-28 rue du Dr. Roux, 75724 Paris, France.
Science. 2001 Oct 26;294(5543):849-52. doi: 10.1126/science.1063447.
Listeria monocytogenes is a food-borne pathogen with a high mortality rate that has also emerged as a paradigm for intracellular parasitism. We present and compare the genome sequences of L. monocytogenes (2,944,528 base pairs) and a nonpathogenic species, L. innocua (3,011,209 base pairs). We found a large number of predicted genes encoding surface and secreted proteins, transporters, and transcriptional regulators, consistent with the ability of both species to adapt to diverse environments. The presence of 270 L. monocytogenes and 149 L. innocua strain-specific genes (clustered in 100 and 63 islets, respectively) suggests that virulence in Listeria results from multiple gene acquisition and deletion events.
单核细胞增生李斯特菌是一种食源性病原体，死亡率很高，它也已成为细胞内寄生的范例。我们展示并比较了单核细胞增生李斯特菌（2944528个碱基对）和一种非致病物种无害李斯特菌（3011209个碱基对）的基因组序列。我们发现大量预测基因编码表面蛋白和分泌蛋白、转运蛋白以及转录调节因子，这与两种物种适应不同环境的能力相一致。270个单核细胞增生李斯特菌菌株特异性基因和149个无害李斯特菌菌株特异性基因（分别聚集在100个和63个基因岛中）的存在表明，李斯特菌的毒力源于多个基因获得和缺失事件。
