热疗对缺氧肿瘤细胞的放射增敏作用。
The radiosensitization of hypoxic tumor cells by hyperthermia.
作者信息
Kim S H, Kim J H, Hahn E W
出版信息
Radiology. 1975 Mar;114(3):727-8. doi: 10.1148/114.3.727.
PMID:1167971
Abstract
The influence of hyperthermia on the survival of irradiated oxic and hypoxic HeLa cells was determined. A significant reduction in OER was obtained for irradiated cells subsequently cultivated at 42-degrees C for two hours compared to irradiated cells cultivated at 37-degrees C. These results suggest that heating irradiated hypoxic cells is an effective means of reducing the oxygen dependence factor in radiation effects.
摘要
测定了热疗对经照射的有氧和缺氧海拉细胞存活的影响。与在37摄氏度培养的经照射细胞相比，随后在42摄氏度培养两小时的经照射细胞的氧增强比（OER）显著降低。这些结果表明，加热经照射的缺氧细胞是降低辐射效应中氧依赖性因子的有效手段。
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