热疗与乏氧细胞增敏剂Ro-07-0582对EMT6小鼠肿瘤的相互作用
Interaction of hyperthermia and the hypoxic cell sensitizer Ro-07-0582 on the EMT6 mouse tumour.
作者信息
Bleehen N M, Honess D J, Morgan J E
出版信息
Br J Cancer. 1977 Mar;35(3):299-306. doi: 10.1038/bjc.1977.43.
Abstract
The combination of hyperthermia and the hypoxic cell radiosensitizer Ro-07-0582 has been investigated on the EMT6 tumour implanted into the legs of BALB/c mice. Treatments at a drug dose of 1 mg/g over a range of waterbath temperatures from 37 to 45 degrees C are described. The surviving clonogenic fraction following treatment was assayed in vitro. Measurements of intra-tumour temperature have been made, and shown to be better correlated with the cytocidal effect on the tumour than the waterbath temperature. No significant effect of Ro-07-0582 was observed at 37 degrees C. However, marked cytotoxicity due to the drug was seen at intra-tumour temperatures above 42-5 degrees C for 1 h. These were in addition to the cytocidal effect of the hyperthermia. The results are discussed in relation to the distribution of temperatures and hypoxic cell populations throughout the tumour.
摘要
已对植入BALB/c小鼠腿部的EMT6肿瘤研究了热疗与乏氧细胞放射增敏剂Ro-07-0582的联合作用。描述了在37至45摄氏度的一系列水浴温度下以1 mg/g的药物剂量进行的治疗。治疗后存活的克隆形成分数在体外进行了测定。已对肿瘤内温度进行了测量，结果表明，与水浴温度相比，肿瘤内温度与对肿瘤的杀细胞作用具有更好的相关性。在37摄氏度时未观察到Ro-07-0582有显著作用。然而，当肿瘤内温度高于42.5摄氏度持续1小时时，可观察到该药物具有明显的细胞毒性。这些作用是在热疗的杀细胞作用之外的。结合整个肿瘤内的温度分布和乏氧细胞群体对结果进行了讨论。
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本文引用的文献
1
Changes of cell proliferation characteristics in a rat rhabdomyosarcoma before and after x-irradiation.
Eur J Cancer (1965). 1969 May;5(2):173-89. doi: 10.1016/0014-2964(69)90065-6.
2
Cellular radiosensitivity and tumor radiation response in the EMT6 tumor cell system.EMT6肿瘤细胞系统中的细胞放射敏感性与肿瘤辐射反应
Radiat Res. 1973 Feb;53(2):281-94.
3
Repair of potentially lethal radiation damage in vitro and in vivo.体内外潜在致死性辐射损伤的修复
Radiology. 1973 Mar;106(3):689-94. doi: 10.1148/106.3.689.
4
Characteristics of a serially transplanted mouse mammary tumor and its tissue-culture-adapted derivative.连续移植的小鼠乳腺肿瘤及其适应组织培养的衍生物的特征。
J Natl Cancer Inst. 1972 Sep;49(3):735-49.
5
Hyperthermia: potential as an anti-tumor agent.
Cancer. 1974 Jul;34(1):122-9. doi: 10.1002/1097-0142(197407)34:1<122::aid-cncr2820340118>3.0.co;2-r.
6
Chemical radiosensitization of hypoxic cells.缺氧细胞的化学放射增敏作用。
Br Med Bull. 1973 Jan;29(1):48-53. doi: 10.1093/oxfordjournals.bmb.a070956.
7
Selective chemotherapy of noncycling cells in an in vitro tumor model.体外肿瘤模型中非循环细胞的选择性化疗。
Cancer Res. 1974 Dec;34(12):3501-3.
8
Killing of Chinese hamster cells in vitro by heating under hypoxic or aerobic conditions.
Eur J Cancer (1965). 1974 Oct;10(10):691-3. doi: 10.1016/0014-2964(74)90009-7.
9
The sensitivity to bleomycin of a solid mouse tumour at different stages of growth.实体小鼠肿瘤在不同生长阶段对博来霉素的敏感性。
Br J Cancer. 1974 Nov;30(5):469-72. doi: 10.1038/bjc.1974.222.
10
[A technique for determining the proportion of the clonogenic cells in S phase in ENT6 cell cultures and tumors].
Cell Tissue Kinet. 1976 Jul;9(4):313-23. doi: 10.1111/j.1365-2184.1976.tb01279.x.
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