Mascarenhas A K, Allen C M, Loudon J
Section of Health Service Research, College of Dentistry, The Ohio State University, Columbus 43218-2357, USA.
Epidemiology. 2001 Nov;12(6):741-3. doi: 10.1097/00001648-200111000-00024.
Recently, leukoplakia of the maxillary vestibule was described in patients with no traditional risk factors but who had used Viadent products. We designed a case-control study to evaluate the hypothesis that Viadent users were more likely to have lesions. One hundred and forty-eight cases and controls were identified through the Section of Oral and Maxillofacial Pathology. Cases and controls were administered a questionnaire about Viadent use and other known risks. Results of crude, stratified, and logistic regression analyses showed that use of Viadent products was a risk indicator for leukoplakia (adjusted OR = 9.7, 95% CI = 4.7-21.6), with a strong dose-response relation.
最近，在上颌前庭白斑患者中发现，这些患者没有传统风险因素，但曾使用过Viadent产品。我们设计了一项病例对照研究，以评估使用Viadent产品的人更易出现病变这一假设。通过口腔颌面病理学部门确定了148例病例和对照。对病例和对照进行了关于Viadent使用及其他已知风险的问卷调查。粗分析、分层分析和逻辑回归分析结果显示，使用Viadent产品是白斑的一个风险指标（校正比值比=9.7，95%置信区间=4.7-21.6），且存在很强的剂量反应关系。
