“特权”肝脏与肝脏免疫耐受性
The "privileged" liver and hepatic tolerogenicity.
作者信息
Starzl T E
机构信息
Thomas E. Starzl Transplantation Institute, 3601 Fifth Ave, Falk Clinic, Pittsburgh, PA 15213, USA.
出版信息
Liver Transpl. 2001 Oct;7(10):918-20. doi: 10.1053/jlts.2001.0070918.
Abstract
The mechanism underlying the immunological advantage of hepatic allografts relative to other organs is incompletely understood. We used molecular probes for the repetitive units on the Y chromosome, to identify an increasing number of male liver venous endothelial cells in needle biopsy samples of men who received female donor liver grafts. We have also shown repopulation of liver endothelium by bone marrow derived cells in a male to female mouse bone marrow transplant model. We conclude that the liver has unique venous endothelium characterized by turnover and replacement by bone marrow derived cells.
摘要
肝移植相对于其他器官所具有的免疫优势背后的机制尚未完全明确。我们使用针对Y染色体上重复单元的分子探针，在接受女性供体肝脏移植的男性患者的针吸活检样本中，识别出越来越多的男性肝静脉内皮细胞。我们还在雄性到雌性的小鼠骨髓移植模型中证明了骨髓来源的细胞可使肝脏内皮细胞实现再填充。我们得出结论，肝脏具有独特的静脉内皮，其特征是可通过骨髓来源的细胞进行更新和替代。
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