活体肝移植的历史视角。
Historical perspective of living donor liver transplantation.
作者信息
Chan See Ching, Fan Sheung Tat
机构信息
Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China.
出版信息
World J Gastroenterol. 2008 Jan 7;14(1):15-21. doi: 10.3748/wjg.14.15.
Abstract
Living donor liver transplantation (LDLT) has gone through its formative years and established as a legitimate treatment when a deceased donor liver graft is not timely or simply not available at all. Nevertheless, LDLT is characterized by its technical complexity and ethical controversy. These are the consequences of a single organ having to serve two subjects, the donor and the recipient, instantaneously. The transplant community has a common ground on assuring donor safety while achieving predictable recipient success. With this background, a reflection of the development of LDLT may be appropriate to direct future research and patient-care efforts on this life-saving treatment alternative.
摘要
活体肝移植（LDLT）已经历了其形成阶段，并在死者供肝不可及时或根本无法获得时成为一种合法的治疗方法。然而，LDLT具有技术复杂性和伦理争议的特点。这些是由于一个单一器官必须同时为两个个体，即供体和受体服务所导致的结果。移植界在确保供体安全的同时实现可预测的受体成功方面有共同的立场。在此背景下，对LDLT的发展进行反思可能有助于指导未来针对这种挽救生命的治疗选择的研究和患者护理工作。
相似文献
1
Historical perspective of living donor liver transplantation.活体肝移植的历史视角。
World J Gastroenterol. 2008 Jan 7;14(1):15-21. doi: 10.3748/wjg.14.15.
2
Living-donor liver transplantation: present status and future perspective.活体肝移植：现状与未来展望。
J Med Invest. 2005 Feb;52(1-2):22-32. doi: 10.2152/jmi.52.22.
3
Evolution of living donor liver transplantation: a global perspective.活体供肝移植的发展：全球视角
J Hepatobiliary Pancreat Sci. 2018 Aug;25(8):388-389. doi: 10.1002/jhbp.571.
4
Living donor liver transplantation: the historical and cultural basis of policy decisions and ongoing ethical questions.活体供肝移植：政策决策的历史文化基础及持续存在的伦理问题。
Health Policy. 2005 May;72(2):175-85. doi: 10.1016/j.healthpol.2004.08.014.
5
Russell W. Strong, FRCS (Eng), FRACS, FRACDS: Pioneering Live Donor Liver Transplantation.拉塞尔·W·斯特朗，英国皇家外科医学院院士（FRCS[Eng]），澳大利亚皇家外科学院院士（FRACS），澳大利亚牙科外科学院院士（FRACDS）：活体肝移植的先驱
Transplantation. 2016 Jun;100(6):1177-9. doi: 10.1097/TP.0000000000001235.
6
Liver transplantation in Asia: past, present and future.亚洲的肝移植：过去、现在与未来
Ann Acad Med Singap. 2009 Apr;38(4):322-10.
7
Comparable short- and long-term outcomes in deceased-donor and living-donor liver retransplantation.在脑死亡供体和活体供体肝移植中具有可比的短期和长期结果。
Hepatol Int. 2017 Nov;11(6):517-522. doi: 10.1007/s12072-017-9821-2. Epub 2017 Sep 21.
8
Defining long-term outcomes with living donor liver transplantation in North America.界定北美活体供肝移植的长期预后。
Ann Surg. 2015 Sep;262(3):465-75; discussion 473-5. doi: 10.1097/SLA.0000000000001383.
9
Living-donor liver transplantation in adults.成人活体肝移植。
Br Med Bull. 2010;94:33-48. doi: 10.1093/bmb/ldq003. Epub 2010 Feb 8.
10
Living donor versus deceased donor liver transplantation: a surgeon-matched comparison of recipient morbidity and outcomes.活体供肝与死体供肝肝移植：受者发病率和结局的外科医生匹配比较。
Transpl Int. 2013 Aug;26(8):780-7. doi: 10.1111/tri.12127. Epub 2013 Jun 7.
引用本文的文献
1
Developing an Adult Living Donor Liver Transplant Program in Western Europe: The Rotterdam Experience.在西欧开展成人活体肝移植项目：鹿特丹经验
Transpl Int. 2025 Jul 10;38:14442. doi: 10.3389/ti.2025.14442. eCollection 2025.
2
Expanding Opportunities for Living Donation: Recommendations From the 2023 Santander Summit to Ensure Donor Protections, Informed Decision Making, and Equitable Access.扩大活体捐赠机会：2023年桑坦德峰会关于确保捐赠者保护、知情决策和公平获取的建议
Transplantation. 2025 Jan 1;109(1):22-35. doi: 10.1097/TP.0000000000005124. Epub 2024 Oct 22.
3
Robotic donor hepatectomy for living donor liver transplantation.用于活体肝移植的机器人供体肝切除术。
Updates Surg. 2024 Sep 18. doi: 10.1007/s13304-024-01932-1.
4
An Elbow Patch Reconstruction Technique for Narrowed Remnant Portal Veins during Right Lobe Living Donor Hepatectomy: A Rescue Surgery.右半肝活体肝移植术中门静脉狭窄残端的肘状补片重建技术：一种补救手术
J Clin Med. 2024 May 16;13(10):2924. doi: 10.3390/jcm13102924.
5
Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantation.亚太肝病学会肝脏移植临床实践指南。
Hepatol Int. 2024 Apr;18(2):299-383. doi: 10.1007/s12072-023-10629-3. Epub 2024 Feb 28.
6
Inventing Engineered Organoids for end-stage liver failure patients.为终末期肝衰竭患者发明工程化类器官。
J Mol Histol. 2022 Aug;53(4):611-621. doi: 10.1007/s10735-022-10085-7. Epub 2022 Jul 27.
7
Pure Laparoscopic vs. Open Right Hepatectomy in Living Liver Donors: Bench-Surgery Time.活体肝供体中单纯腹腔镜与开放性右半肝切除术：手术台时间
Front Surg. 2021 Nov 23;8:771026. doi: 10.3389/fsurg.2021.771026. eCollection 2021.
8
Living Donor Liver Transplantation in the United States: Evolution of Frequency, Outcomes, Center Volumes, and Factors Associated With Outcomes.美国活体供肝移植：频率、结果、中心容量的演变，以及与结果相关的因素。
Liver Transpl. 2021 Jul;27(7):1019-1031. doi: 10.1002/lt.26029. Epub 2021 Jun 24.
9
Health-related quality of life after anonymous nondirected living liver donation: A multicenter collaboration.非定向活体肝移植供者的健康相关生活质量：多中心合作。
Am J Transplant. 2021 Mar;21(3):1056-1067. doi: 10.1111/ajt.16229. Epub 2020 Sep 3.
10
Outcome of right hepatectomy for living liver donors: a single Egyptian center experience.右半肝活体肝移植供者的结局：埃及单中心经验。
J Gastrointest Surg. 2012 Jun;16(6):1181-8. doi: 10.1007/s11605-012-1851-4. Epub 2012 Feb 28.
本文引用的文献
1
Death of a living liver donor from illicit drugs.一名活体肝脏供体因非法药物死亡。
Liver Transpl. 2007 Aug;13(8):1193-4. doi: 10.1002/lt.21240.
2
Continuous versus interrupted suture for end-to-end biliary anastomosis during liver transplantation gives equal results.肝移植术中端端胆管吻合采用连续缝合与间断缝合效果相同。
Liver Transpl. 2007 Feb;13(2):234-8. doi: 10.1002/lt.20986.
3
Toward current standards of donor right hepatectomy for adult-to-adult live donor liver transplantation through the experience of 200 cases.通过200例成人对成人活体肝移植供体右肝切除术的经验，迈向当前的标准。
Ann Surg. 2007 Jan;245(1):110-7. doi: 10.1097/01.sla.0000225085.82193.08.
4
Living donor versus deceased donor liver transplantation for early irresectable hepatocellular carcinoma.活体供体与尸体供体肝移植治疗早期不可切除肝细胞癌
Br J Surg. 2007 Jan;94(1):78-86. doi: 10.1002/bjs.5528.
5
Live donor liver transplantation in adults.成人活体肝移植
Transplantation. 2006 Sep 27;82(6):723-32. doi: 10.1097/01.tp.0000235171.17287.f2.
6
Documented deaths of hepatic lobe donors for living donor liver transplantation.活体肝移植供体肝叶供者的死亡记录。
Liver Transpl. 2006 Oct;12(10):1485-8. doi: 10.1002/lt.20875.
7
A report of the Vancouver Forum on the care of the live organ donor: lung, liver, pancreas, and intestine data and medical guidelines.温哥华活体器官捐献者护理论坛报告：肺、肝、胰和肠数据及医学指南
Transplantation. 2006 May 27;81(10):1373-85. doi: 10.1097/01.tp.0000216825.56841.cd.
8
Estimating liver weight of adults by body weight and gender.通过体重和性别估算成年人的肝脏重量。
World J Gastroenterol. 2006 Apr 14;12(14):2217-22. doi: 10.3748/wjg.v12.i4.2217.
9
Operative outcomes of adult-to-adult right lobe live donor liver transplantation: a comparative study with cadaveric whole-graft liver transplantation in a single center.成人对成人右叶活体肝移植的手术结果：单中心与尸体全肝移植的比较研究。
Ann Surg. 2006 Mar;243(3):404-10. doi: 10.1097/01.sla.0000201544.36473.a2.
10
Long-term biological consequences of donor right hepatectomy including the middle hepatic vein in adult-to-adult live donor liver transplantation.成人对成人活体肝移植中供体右半肝切除（包括肝中静脉）的长期生物学后果。
Liver Transpl. 2006 Feb;12(2):259-63. doi: 10.1002/lt.20565.
Zotero 插件