Ghassemifard Leila, Hasanlu Masumeh, Parsamanesh Negin, Atkin Stephen L, Almahmeed Wael, Sahebkar Amirhossein
Department of Physiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Department of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Curr Diabetes Rev. 2025;21(8):e130524229899. doi: 10.2174/0115733998292392240425122326.
The epidemic of diabetes continues to be an increasing problem, and there is a need for new therapeutic strategies. There are several promising drugs and molecules in synthetic medicinal chemistry that are developing for diabetes. In addition to this approach, extensive studies with gene and cell therapies are being conducted. Gene therapy is an existing approach in treating several diseases, such as cancer, autoimmune diseases, heart disease and diabetes. Several reports have also suggested that stem cells have the differentiation capability to functional pancreatic beta cell development in vitro and in vivo, with the utility to treat diabetes and prevent the progression of diabetes-related complications. In this current review, we have focused on the different types of cell therapies and vector-based gene therapy in treating or preventing diabetes.
糖尿病的流行仍然是一个日益严重的问题，因此需要新的治疗策略。在合成药物化学领域，有几种有前景的药物和分子正在研发用于治疗糖尿病。除了这种方法外，针对基因和细胞疗法也在进行广泛研究。基因疗法是治疗多种疾病（如癌症、自身免疫性疾病、心脏病和糖尿病）的一种现有方法。一些报告还表明，干细胞在体外和体内具有分化为功能性胰腺β细胞的能力，可用于治疗糖尿病并预防糖尿病相关并发症的进展。在本综述中，我们重点关注了治疗或预防糖尿病的不同类型的细胞疗法和基于载体的基因疗法。
