Di Marco P, Grippaudo F R, Della Rocca G, De Vita R
Department of Anesthesiology, University of Rome La Sapienza, Rome, Italy.
Scand J Plast Reconstr Surg Hand Surg. 2001 Sep;35(3):297-300. doi: 10.1080/028443101750523212.
Pre-emptive analgesia is an antinociceptive treatment that prevents altered central excitability from high intensity noxious stimuli. The aim of this study was to evaluate the efficacy of pre-emptive analgesia in patients due to have elective breast reduction that usually requires drugs for postoperative pain control. Sixty women, ASA grades I-II, were randomly divided into two groups: 30 patients were given ropivacaine infiltration 1.5 mg/ml plus adrenaline 1/200,000 in normal saline 100 ml before the skin incision, and 30 had normal saline 100 ml plus adrenaline 1/200,000 infiltrated. Postoperative pain was evaluated by an observer who was unaware of the treatment given, and scored on a visual analogue score (VAS) during the first 72 hours postoperatively. Analgesic requirements were recorded. There was a statistically significant difference between groups in the amount of additional pain control required during the early postoperative period, which suggests that pre-emptive analgesia reduces pain after reduction mammaplasty.
超前镇痛是一种抗伤害性感受治疗，可防止高强度伤害性刺激引起的中枢兴奋性改变。本研究的目的是评估超前镇痛对择期行乳房缩小术患者的疗效，这类手术通常需要使用药物控制术后疼痛。60名美国麻醉医师协会（ASA）分级为I-II级的女性被随机分为两组：30名患者在皮肤切口前接受1.5mg/ml罗哌卡因加1/200,000肾上腺素的100ml生理盐水浸润，另外30名患者接受100ml生理盐水加1/200,000肾上腺素浸润。由不知道所给予治疗的观察者评估术后疼痛，并在术后72小时内使用视觉模拟评分法（VAS）进行评分。记录镇痛需求。术后早期两组在额外疼痛控制量方面存在统计学显著差异，这表明超前镇痛可减轻乳房缩小术后的疼痛。
