植物类黄酮的抗炎特性。芦丁、槲皮素和橙皮苷对大鼠佐剂性关节炎的影响。
Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat.
作者信息
Guardia T, Rotelli A E, Juarez A O, Pelzer L E
机构信息
Departamento de Farmacia, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Argentina.
出版信息
Farmaco. 2001 Sep;56(9):683-7. doi: 10.1016/s0014-827x(01)01111-9.
Abstract
The anti-inflammatory activities of three flavonoids were investigated in rats using the Mizushima et al. model of acute and chronic inflammation. Intraperitoneal administration of rutin, quercetin (flavonols) and hesperidin (flavanone), given at daily doses equivalent to 80 mg/kg, inhibited both acute and chronic phases of this experimental model of inflammation. Rutin was the most active in the chronic phase.
摘要
使用水岛等人的急慢性炎症模型，在大鼠中研究了三种黄酮类化合物的抗炎活性。腹腔注射芦丁、槲皮素（黄酮醇）和橙皮苷（黄烷酮），每日剂量相当于80毫克/千克，抑制了该实验性炎症模型的急性期和慢性期。芦丁在慢性期最具活性。
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