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洗必泰的细胞毒性

Cytotoxicity of chlorhexidine.

作者信息

Gasset A R, Ishii Y

出版信息

Can J Ophthalmol. 1975 Jan;10(1):98-100.

PMID:1168090
Abstract

We evaluated chlorhexidine, a commonly used ophthalmic preservative for sterilization of soft hydrophilic contact lenses. Light microscopy and flat preparations of the endothelium were used. Our studies indicate that chlorhexidine is safe, even when used in higher concentrations than commercially available or required for bactericidal effect. Except for its mucous binding capacity, limiting its use for hydrophilic contact lenses, it is considered to be one of the best preservatives available for ophthalmic solutions.

摘要

我们评估了洗必泰,一种常用于软性亲水接触镜消毒的眼科防腐剂。采用了光镜检查和内皮细胞平铺标本。我们的研究表明,洗必泰是安全的,即使使用浓度高于市售浓度或杀菌所需浓度也是如此。除了其黏液结合能力限制了它在亲水接触镜中的应用外,它被认为是眼科溶液中可用的最佳防腐剂之一。

相似文献

1
Cytotoxicity of chlorhexidine.洗必泰的细胞毒性
Can J Ophthalmol. 1975 Jan;10(1):98-100.
2
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Chlorhexidine effects on corneal epithelium and endothelium.洗必泰对角膜上皮和内皮的影响。
Arch Ophthalmol. 1980 Jul;98(7):1273-8. doi: 10.1001/archopht.1980.01020040125020.
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J Ocul Pharmacol Ther. 2017 Apr;33(3):202-209. doi: 10.1089/jop.2016.0053.
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Cytotoxicity of rigid gas-permeable lens care solutions.硬性透气性隐形眼镜护理液的细胞毒性
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[Delayed healings of the epithelium of the cornea due to soft lenssolutions].[软性隐形眼镜护理液导致角膜上皮愈合延迟]
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Clin Optom (Auckl). 2021 Sep 7;13:271-285. doi: 10.2147/OPTO.S235679. eCollection 2021.
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Cytotoxicity assays of new artificial tears containing 2-methacryloyloxyethyl phosphorylcholine polymer for ocular surface cells.
新型人工泪液中含有 2-甲基丙烯酰氧乙基磷酰胆碱聚合物对眼表细胞的细胞毒性研究。
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[Single-use intermittent catheterisation].[一次性间歇性导尿术]
Urologe A. 2006 Feb;45(2):175-82. doi: 10.1007/s00120-006-1007-9.
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Randomised trial of 0.2% chlorhexidine gluconate and 2.5% natamycin for fungal keratitis in Bangladesh.孟加拉国0.2%葡萄糖酸氯己定和2.5%那他霉素治疗真菌性角膜炎的随机试验
Br J Ophthalmol. 1998 Aug;82(8):919-25. doi: 10.1136/bjo.82.8.919.
6
Experimental evaluation of chlorhexidine gluconate for ocular antisepsis.葡萄糖酸氯己定用于眼部消毒的实验评估
Antimicrob Agents Chemother. 1984 Dec;26(6):793-6. doi: 10.1128/AAC.26.6.793.