Chen C Y, Byrne H M, King J R
Division of Theoretical Mechanics, School of Mathematical Science, The University of Nottingham, UK.
J Math Biol. 2001 Sep;43(3):191-220. doi: 10.1007/s002850100091.
A mathematical model is adapted to the description of the growth of an avascular tumour spheroid embedded in a deformable medium (gel). Attention is focused on the influence that the mechanical properties of the gel have on the tumour's growth dynamics. Following the work of Landman and Please (2000), the tumour is treated as a two phase material, whereby the tumour cells and the extracellular fluid form distinct phases. Its growth is modelled by combining mass conservation and force balances for each phase with the usual concepts of diffusion limited growth in response to an externally supplied nutrient. The mechanical properties of the gel are characterised by a strain energy function. The stress induced in the gel by the tumour's expansion is incorporated into the force balance equations, thereby linking it to the tumour's growth. Numerical simulations of the model equations show that as the stiffness of the gel increases, the tumour's growth rate and equilibrium size decrease and the time at which necrosis is initiated is delayed (if it occurs at all). Similar results are obtained when the initial size of the tumour is reduced whilst the mechanical properties of the surrounding gel are held fixed. Such results, which are in good qualitative agreement with available experimental data, suggest that mechanical interactions between a tumour and the tissue or medium in which it is located can significantly influence its growth dynamics.
一个数学模型适用于描述嵌入可变形介质(凝胶)中的无血管肿瘤球体的生长。重点关注凝胶的力学性能对肿瘤生长动力学的影响。遵循兰德曼和普利斯(2000年)的工作,将肿瘤视为两相材料,其中肿瘤细胞和细胞外液形成不同的相。通过将各相的质量守恒和力平衡与响应外部供应营养物质的扩散受限生长的常用概念相结合,对其生长进行建模。凝胶的力学性能由应变能函数表征。肿瘤膨胀在凝胶中引起的应力被纳入力平衡方程,从而将其与肿瘤的生长联系起来。模型方程数值模拟表明,随着凝胶刚度增加,肿瘤生长速率和平衡尺寸减小,坏死开始时间延迟(如果坏死发生的话)。当肿瘤初始尺寸减小而周围凝胶力学性能保持不变时,也会得到类似结果。这些结果与现有实验数据在定性上吻合良好,表明肿瘤与其所在组织或介质之间的力学相互作用可显著影响其生长动力学。