Goodwin R, Lipsitz J D, Chapman T F, Mannuzza S, Fyer A J
Department of Psychiatry, Columbia University College of Physicians and Surgeons/New York State Psychiatric Institute, New York 10032, USA.
Psychol Med. 2001 Oct;31(7):1307-10. doi: 10.1017/s0033291701004366.
This study was undertaken to examine the relationship between anxiety co-morbidity and age of onset of panic disorder.
Age of onset of panic disorder and co-morbid anxiety disorders were assessed among 201 panic disorder probands with childhood separation anxiety disorder, obsessive-compulsive disorder, obsessive-compulsive symptoms, social phobia and specific phobia as part of a clinician-administered lifetime diagnostic interview. A generalized linear model was used to test the association between each anxiety co-morbidity and age of panic disorder onset while simultaneously controlling for the potential confounding effects of sociodemographic characteristics and other psychiatric co-morbidity.
Earlier onset of panic disorder was found in patients with co-morbid obsessive-compulsive disorder, obsessive-compulsive symptoms and separation anxiety disorder, but not simple phobia or social phobia. Patients with both childhood separation anxiety disorder and obsessive-compulsive disorder had an even earlier panic onset than those with either childhood separation anxiety disorder or obsessive-compulsive disorder.
The association between anxiety co-morbidity and earlier onset of panic disorder is specific to obsessive-compulsive disorder and childhood separation anxiety disorder.
本研究旨在探讨惊恐障碍共病焦虑与惊恐障碍发病年龄之间的关系。
在201名惊恐障碍先证者中评估惊恐障碍的发病年龄以及共病的焦虑障碍，这些先证者患有儿童期分离性焦虑障碍、强迫症、强迫症状、社交恐惧症和特定恐惧症，作为临床医生进行的终生诊断访谈的一部分。使用广义线性模型来检验每种焦虑共病与惊恐障碍发病年龄之间的关联，同时控制社会人口学特征和其他精神共病的潜在混杂效应。
发现共病强迫症、强迫症状和分离性焦虑障碍的患者惊恐障碍发病较早，但单纯恐惧症或社交恐惧症患者并非如此。同时患有儿童期分离性焦虑障碍和强迫症的患者惊恐发作比仅患有儿童期分离性焦虑障碍或强迫症的患者更早。
焦虑共病与惊恐障碍较早发病之间的关联特定于强迫症和儿童期分离性焦虑障碍。
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