Perna G, Bertani A, Arancio C, Ronchi P, Bellodi L
Department of Neuropsychiatric Sciences, San Raffaele Hospital, University of Milan, Italy.
Am J Psychiatry. 1995 Jan;152(1):85-9. doi: 10.1176/ajp.152.1.85.
The DSM-III-R anxiety disorders section includes both panic disorder and obsessive-compulsive disorder. To evaluate the relationship between these two disorders, subject responses to inhalation of a 35% CO2 and 65% O2 mixture were assessed.
Twenty-three patients with panic disorder, 23 with obsessive-compulsive disorder, 12 with both obsessive-compulsive and panic disorder, and 23 healthy comparison subjects were given a single vital capacity inhalation of 35% CO2 and 65% O2 or a placebo mixture of compressed air. A double-blind, random, crossover design was used.
Patients with panic disorder and patients with both panic disorder and obsessive-compulsive disorder showed similar strong anxiogenic reactions to 35% CO2; while patients with obsessive-compulsive disorder alone did not differ from comparison subjects.
These results confirm that obsessive-compulsive disorder and panic disorder are two distinct syndromes and that patients with these disorders have different sensitivity to CO2 inhalation.
《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）中的焦虑症章节包括惊恐障碍和强迫症。为评估这两种障碍之间的关系，对受试者吸入35%二氧化碳和65%氧气混合气体后的反应进行了评估。
23名惊恐障碍患者、23名强迫症患者、12名同时患有强迫症和惊恐障碍的患者以及23名健康对照受试者接受了一次肺活量的35%二氧化碳和65%氧气混合气体或压缩空气安慰剂混合气体吸入。采用双盲、随机、交叉设计。
惊恐障碍患者以及同时患有惊恐障碍和强迫症的患者对35%二氧化碳表现出相似的强烈致焦虑反应；而单纯强迫症患者与对照受试者无差异。
这些结果证实强迫症和惊恐障碍是两种不同的综合征，且患有这些障碍的患者对二氧化碳吸入有不同的敏感性。
