环磷酰胺对由强毒株和无毒株流感病毒引起的小鼠感染的影响。
Effect of cyclophosphamide on infections in mice caused by virulent and avirulent strains of influenza virus.
作者信息
Hurd J, Heath R B
出版信息
Infect Immun. 1975 May;11(5):886-9. doi: 10.1128/iai.11.5.886-889.1975.
Abstract
Induced immunosuppression with the drug cyclophosphamide was shown to convert the relatively harmless infection with an avirulent strain of Kunz influenza virus into a fatal pneumonic illness. The drug was also shown to increase the mortality of mice infected with low concentrations of a virulent variant of this strain, but it delayed the time of death of mice that were infected with high concentrations ofthe same variant. The probable roles of immune and inflammatory mechanisms in recovery from primary influenza virus infections are discussed.
摘要
已证实，使用环磷酰胺药物诱导免疫抑制会使感染无毒株昆兹流感病毒的相对无害的感染转变为致命的肺炎疾病。还表明该药物会增加感染该毒株低浓度强毒株变体的小鼠的死亡率，但会延迟感染相同变体高浓度的小鼠的死亡时间。文中讨论了免疫和炎症机制在原发性流感病毒感染恢复过程中的可能作用。
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