环磷酰胺处理小鼠的呼吸道疾病。II. PR8流感病毒毒力降低
Respiratory diseases in cyclophosphamide-treated mice. II. Decreased virulence of PR8 influenza virus.
作者信息
Singer S H, Noguchi P, Kirschstein R L
出版信息
Infect Immun. 1972 Jun;5(6):957-60. doi: 10.1128/iai.5.6.957-960.1972.
Abstract
Mice infected intranasally with the PR8 strain of influenza virus were treated with cyclophosphamide, a potent immunologic suppressor. During the first week of infection, mortality in the unmodified influenza infection averaged 65%, whereas in those animals also treated with cyclophosphamide it averaged 22.5%. After the first week, the mortality rate in the infected cyclophosphamide-treated animals rose to that seen during the first week in the animals only infected. This decreased mortality in the first week was found despite the fact that the cyclophosphamide-treated and infected animals had higher virus titers which persisted longer, decreased circulating antibody, and a decreased interferon response. This delayed mortality appeared to be related to the finding of decreased cellular infiltration in the lungs of infected cyclophosphamide-treated animals.
摘要
用环磷酰胺（一种强效免疫抑制剂）对经鼻内感染流感病毒PR8株的小鼠进行治疗。在感染的第一周，未接受治疗的流感感染小鼠的死亡率平均为65%，而在同时接受环磷酰胺治疗的小鼠中，死亡率平均为22.5%。第一周后，接受环磷酰胺治疗的感染动物的死亡率上升至仅感染动物在第一周时的死亡率。尽管接受环磷酰胺治疗并感染的动物病毒滴度更高且持续时间更长、循环抗体减少以及干扰素反应降低，但仍发现第一周死亡率降低。这种延迟的死亡率似乎与在接受环磷酰胺治疗并感染的动物肺部发现细胞浸润减少有关。
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