环磷酰胺处理小鼠的呼吸道疾病。I. 肺支原体毒力增强。
Respiratory diseases in cyclophosphamide-treated mice. I. Increased virulence of Mycoplasma pulmonis.
作者信息
Singer S H, Ford M, Kirschstein R L
出版信息
Infect Immun. 1972 Jun;5(6):953-6. doi: 10.1128/iai.5.6.953-956.1972.
Abstract
Mice infected intranasally with Mycoplasma pulmonis were treated with cyclophosphamide, a potent immunologic suppressor. In place of a chronic smouldering infection with little mortality (2%), a rapidly lethal infection with high mortality (66%) was produced. M. pulmonis was able to be isolated from several organs during the course of the unmodified infection. In the infected animals treated with cyclophosphamide, dissemination occurred earlier, and higher titers of mycoplasma were found. Reconstitution experiments with spleen cells from previously infected animals reversed the effect of cyclophosphamide, indicating that immunity plays an important role in containment of the infection and eventual recovery.
摘要
用强效免疫抑制剂环磷酰胺治疗经鼻内感染肺支原体的小鼠。原本是几乎没有死亡率（2%）的慢性隐匿性感染，却产生了死亡率很高（66%）的快速致死性感染。在未改变的感染过程中，能够从多个器官中分离出肺支原体。在用环磷酰胺治疗的感染动物中，传播更早发生，并且发现支原体滴度更高。用先前感染动物的脾细胞进行的重建实验逆转了环磷酰胺的作用，表明免疫在控制感染和最终恢复中起重要作用。
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