Eastwood M, Mowbray L
Am J Clin Nutr. 1976 Dec;29(12):1461-7. doi: 10.1093/ajcn/29.12.1461.
Bile acid conjugates are adsorbed to cereal fiber. Bile acid conjugates incorporated into micelles with cholesterol are reversibly adsorbed as micelles on to the fiber. Incorporating bile acid conjugates into micelles with monoglycerides somewhat depresses adsorption of bile acid conjugate. If fatty acids, monoglycerides, and bile acid conjugate mixed micelles are exposed to cereal fiber, then adsorption of bile acids to the fiber is diminished. The extent to which the adsorption is diminished is affected by the fatty acid concentration, chain length, and unsaturation. This suggests that bile acid conjugates are minimally adsorbed to fiber in the jejunum but deconjugation and dehydroxylation as in the cecum favors adsorption.
胆汁酸共轭物会吸附到谷物纤维上。与胆固醇结合形成微团的胆汁酸共轭物会以微团的形式可逆地吸附到纤维上。将胆汁酸共轭物与甘油单酯结合形成微团会在一定程度上抑制胆汁酸共轭物的吸附。如果脂肪酸、甘油单酯和胆汁酸共轭物混合微团与谷物纤维接触,那么胆汁酸对纤维的吸附就会减少。吸附减少的程度受脂肪酸浓度、链长和不饱和度的影响。这表明胆汁酸共轭物在空肠中对纤维的吸附极少,但在盲肠中发生的去共轭和脱羟基作用有利于吸附。