Borum M L, Shehan K L, Fromm H, Jahangeer S, Floor M K, Alabaster O
Department of Medicine, George Washington University Medical Center, Washington, D.C. 20037.
Lipids. 1992 Dec;27(12):999-1004. doi: 10.1007/BF02535579.
The effect and possible interactive influence of different dietary amounts of wheat bran, fat and calcium on the fecal excretion, concentration and composition of bile acids was studied in Fischer-344 rats. The fecal bile acids were analyzed using gas-liquid chromatography. Dietary wheat bran increased both total bile acid excretion and fecal weight without changes in fecal bile acid concentration. The proportion of fecal hyodeoxycholic acid decreased with increasing dietary fiber, whereas that of lithocholic and deoxycholic acids increased significantly with fiber intake. The percent content of fecal chenodeoxycholic acid did not change. Increasing dietary fat led to an increase in bile acid excretion without changes in either fecal weight or bile acid concentration. In contrast, the level of dietary calcium did not affect the total excretion of bile acids. However, since calcium increased the fecal weight, it consequently diluted bile acids and decreased their fecal concentration. Dietary fat and calcium had no influence on fecal bile acid composition. There were no interactive effects of wheat bran, fat and calcium on fecal bile acids. The finding in this study that dietary fiber, fat and calcium induce significant changes in fecal bile acids may be of relevance to the potential of bile acids to promote carcinogenesis.
在Fischer-344大鼠中研究了不同膳食量的麦麸、脂肪和钙对粪便胆汁酸排泄、浓度及组成的影响以及可能的交互作用。采用气液色谱法分析粪便胆汁酸。膳食麦麸增加了总胆汁酸排泄量和粪便重量，而粪便胆汁酸浓度无变化。随着膳食纤维摄入量增加，粪便猪去氧胆酸比例降低，而石胆酸和脱氧胆酸比例则随纤维摄入量显著增加。粪便鹅去氧胆酸的百分比含量未改变。膳食脂肪增加导致胆汁酸排泄增加，而粪便重量和胆汁酸浓度均无变化。相反，膳食钙水平不影响胆汁酸的总排泄量。然而，由于钙增加了粪便重量，因此稀释了胆汁酸并降低了其粪便浓度。膳食脂肪和钙对粪便胆汁酸组成无影响。麦麸、脂肪和钙对粪便胆汁酸无交互作用。本研究中关于膳食纤维、脂肪和钙可引起粪便胆汁酸显著变化的发现，可能与胆汁酸促进致癌作用的潜在影响有关。
