Calhoun K S, Prewett M J, Peters R D, Adams H E
J Comp Physiol Psychol. 1975 Jan;88(1):373-7. doi: 10.1037/h0076189.
It has been demonstrated that placing rats in a sensory-restricted environment during the electronconvulsive shock- (ECS) retention interval following 1-trial appetitive learning will prevent or eliminate ECS-produced retrograde amnesia. The first study replicated this finding with a 1-trial aversive learning task, indicating that this effect is not task specific. The second study attempted to determine whether illumination or the restricted environment was the crucial factor in this penomenon. Rats placed in the light during the ECS-retention interval, whether restricted or in the colony, demonstrated retrograde amnesia after ECS. However, rats left in the dark during this interval demonstrated little, if any, retention deficit particularly if this condition was combined with sensory isolation. These studies further indicate that manipulation of the general environment of the animal after ECS can alter ECS-produced retention losses.
业已证明，在单次尝试性食欲学习后的电惊厥休克（ECS）记忆保持间隔期，将大鼠置于感觉受限环境中，可预防或消除ECS引起的逆行性遗忘。第一项研究通过单次尝试性厌恶学习任务重复了这一发现，表明这种效应并非特定于某种任务。第二项研究试图确定光照或受限环境是否是这一现象的关键因素。在ECS记忆保持间隔期置于光亮处的大鼠，无论处于受限环境还是群体环境，在ECS后均表现出逆行性遗忘。然而，在此间隔期置于黑暗中的大鼠，即使有记忆保持缺陷也很轻微，特别是当这种情况与感觉隔离相结合时。这些研究进一步表明，在ECS后对动物的一般环境进行操控可改变ECS引起的记忆保持损失。
