β-（酪氨酰9）促黑素-（9-18）对大鼠主动回避行为、电惊厥休克所致失忆及T形辨别学习的影响。

The effect of beta-(Tyr9)melanotropin-(9-18) on active avoidance behavior, electroconvulsive shock-induced amnesia and T-discrimination learning of rats.

作者信息

Telegdy G, Vécsei L, Bollók I, Schally A V

出版信息

Peptides. 1986 Jan-Feb;7(1):11-3. doi: 10.1016/0196-9781(86)90053-7.

Abstract

The effect of beta-(Tyr9)melanotropin-(9-18) was investigated on active avoidance behavior, electroconvulsive shock (ECS)-induced amnesia and T-discrimination learning in rats. The decapeptide inhibited the extinction of active avoidance behavior. It was also able to block ECS-induced amnesia if the treatment was performed immediately, or 4 hr or 20 hr after the ECS. In the T-discrimination paradigm the peptide facilitated spatial discrimination learning and reversal learning. These results suggest that beta-(Tyr9)melanotropin-(9-18) can influence learning and memory processes in different behavioral tests.

摘要

研究了β-（酪氨酰9）促黑素（9 - 18）对大鼠主动回避行为、电惊厥休克（ECS）诱导的失忆及T形辨别学习的影响。该十肽抑制主动回避行为的消退。如果在ECS后立即、4小时或20小时进行处理，它也能够阻断ECS诱导的失忆。在T形辨别范式中，该肽促进空间辨别学习和逆向学习。这些结果表明，β-（酪氨酰9）促黑素（9 - 18）在不同行为测试中可影响学习和记忆过程。