Hassan E M, Belal F
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, -11451, Riyadh, Saudi Arabia.
J Pharm Biomed Anal. 2002 Jan 1;27(1-2):31-8. doi: 10.1016/s0731-7085(01)00473-3.
A new simple and sensitive kinetic spectrophotometric method is described for analysis of nizatidine (I) and ranitidine (II). The method involves the reaction of the drugs with alkaline potassium permanganate, whereby a green color peaking at 610 nm is produced. The reaction is monitored spectrophotometrically by measuring the rate of change of absorbance of the resulting manganate species at 610 nm. Calibration graphs are linear over the concentration range 0.8-4.0 microg/ml and the precision (% RSD 1.80, 1.53 for I and II, respectively) is quite acceptable. The method is satisfactorily applied for direct analysis of pharmaceutical preparations containing I and II. A proposal of the reaction pathway is postulated.
描述了一种用于分析尼扎替丁（I）和雷尼替丁（II）的新的简单灵敏的动力学分光光度法。该方法涉及药物与碱性高锰酸钾的反应，由此产生在610nm处有峰值的绿色。通过测量所得锰酸盐物种在610nm处吸光度的变化速率，用分光光度法监测该反应。校准曲线在0.8 - 4.0μg/ml的浓度范围内呈线性，精密度（I和II的相对标准偏差分别为1.80%、1.53%）相当令人满意。该方法成功地应用于直接分析含有I和II的药物制剂。提出了反应途径的假设。
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