敌敌畏对大鼠发情周期启动的影响。
Dichlorvos effects on estrous cycle onset in the rat.
作者信息
Timmons E H, Chaklos R J, Bannister T M, Kaplan H M
出版信息
Lab Anim Sci. 1975 Feb;25(1):45-7.
PMID:1168291
Abstract
Continuous exposure to dichlorvos (DDVP) vapors from birth in rats caused a statistically significant mean delay of 10 da in the onset of the first estrous cycle. DDVP, BUT NOT ITS PRIMARY METABOLITE (DES-METHYL DDVP), could be readily isolated from blood and ovarian tissue, and occassionally in minute quantities from the kidney and adrenal tissues. DDVP was recovered only once in 40 brain tissue samples examined.
摘要
大鼠从出生起持续接触敌敌畏（DDVP）蒸汽，导致首次发情周期开始时平均延迟10天，这在统计学上具有显著意义。敌敌畏而非其主要代谢产物（去甲基敌敌畏），能够很容易地从血液和卵巢组织中分离出来，偶尔也能从肾脏和肾上腺组织中分离出少量。在检测的40份脑组织样本中，仅一次检测到敌敌畏。
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