Goldstein F, Thornton J J, Abramson J
Am J Gastroenterol. 1976 Sep;66(3):251-8.
In a prospective evaluation of all patients with Crohn's disease treated by us since 1970, 62 have completed at least one year, or required bowel resection after at least three months, of anti-inflammatory drug treatment. Sulfasalazine alone was used in 24 patients, steroids alone were used in four patients, both drugs were used together in 29 patients and azathioprine was added to the drug regimen of five patients. The initial choice of drug followed a set design but the regimens ultimately arrived at depended upon patient responses. Favorable complete or partial clinical responses were obtained in 54 patients, while 37 patients showed objective radiographic improvement or regression. No radiographic improvement was found in the eight patients with clinical treatment failure as well as in 11 patients with clinical improvement. Six clinically improved patients had not yet been re-examined radiographically. The study provides objective evidence that the majority of patients with Crohn's disease can be successfully treated by means of anti-inflammatory drugs.
在对1970年以来我们治疗的所有克罗恩病患者进行的前瞻性评估中，62例患者完成了至少一年的抗炎药物治疗，或在至少三个月后需要进行肠切除。24例患者仅使用柳氮磺胺吡啶，4例患者仅使用类固醇，29例患者同时使用这两种药物，5例患者的药物治疗方案中加用了硫唑嘌呤。药物的初始选择遵循既定方案，但最终采用的方案取决于患者的反应。54例患者获得了良好的完全或部分临床反应，37例患者影像学检查显示有客观改善或病变消退。8例临床治疗失败的患者以及11例有临床改善的患者影像学检查均未发现改善。6例临床症状改善的患者尚未进行影像学复查。该研究提供了客观证据，表明大多数克罗恩病患者可以通过抗炎药物成功治疗。
