肺炎并发于甲氨蝶呤治疗脓疱型银屑病过程中。

Pneumonitis complicating methotrexate therapy for pustular psoriasis.

作者信息

Ameen M, Taylor D A, Williams I P, Wells A U, Barkert J N

机构信息

St Johnś Institute of Dermatology, St Thomas' Hospital, London, UK.

出版信息

J Eur Acad Dermatol Venereol. 2001 May;15(3):247-9. doi: 10.1046/j.1468-3083.2001.t01-1-00223.x.

DOI:10.1046/j.1468-3083.2001.t01-1-00223.x

PMID:11683290

Abstract

We report a patient with pustular psoriasis who developed interstitial pneumonitis after receiving weekly methotrexate (MTX) therapy at an average dose of 20 mg for 26 years. The patient responded dramatically to withdrawal of the drug and administration of corticosteroids. Pulmonary toxicity is a rare adverse effect of MTX therapy and is particularly uncommon in psoriatics. As interstitial pneumonitis is a potentially fatal but reversible complication, early respiratory symptoms even in patients on low-dose MTX treatment should be appropriately investigated.

摘要

我们报告了一名脓疱型银屑病患者，该患者在接受平均剂量为20毫克的每周一次甲氨蝶呤（MTX）治疗26年后发生了间质性肺炎。患者对停药和给予皮质类固醇治疗反应显著。肺部毒性是MTX治疗罕见的不良反应，在银屑病患者中尤为少见。由于间质性肺炎是一种潜在致命但可逆转的并发症，即使是接受低剂量MTX治疗的患者出现早期呼吸道症状也应进行适当检查。