Ishikawa Genta, Dua Sakshi, Mathur Aditi, Acquah Samuel O, Salvatore Mary, Beasley Mary B, Padilla Maria L
Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Radiology, Columbia University Medical Center, New York, NY, USA.
Can Respir J. 2019 Aug 25;2019:5919304. doi: 10.1155/2019/5919304. eCollection 2019.
We encounter interstitial lung disease (ILD) patients with psoriasis. The aim of this case series was to examine clinical and radiographic characteristics of patients with concomitant psoriasis and ILD.
This is a retrospective review of our institutional experience of ILD concomitant with psoriasis, from the database in the Advanced Lung/Interstitial Lung Disease Program at the Mount Sinai Hospital. Out of 447 ILD patients, we identified 21 (4.7%) with antecedent or concomitant diagnosis of psoriasis. Clinical, radiographic, pathological, and outcome data were abstracted from our medical records.
Median age was 66 years (range, 46-86) and 14 (66.7%) were male. Thirteen (61.9%) had not previously or concomitantly been exposed to immunosuppressive therapy directed against psoriasis. Two (9.5%) ultimately died. Clinical diagnosis of ILD included idiopathic pulmonary fibrosis, 11 (52.4%); nonspecific interstitial pneumonia (NSIP), 2 (9.5%); cryptogenic organizing pneumonia, 2 (9.5%); chronic hypersensitivity pneumonitis, 2 (9.5%); and the others, while radiographic diagnosis included usual interstitial pneumonia pattern, 9 (42.9%); NSIP pattern, 6 (28.6%); organizing pneumonia pattern, 4 (19.0%); hypersensitivity pneumonitis pattern, 2 (9.5%); and the others.
We report 21 ILD cases with antecedent or concomitant diagnosis of psoriasis. Further prospective studies are required to determine the association between ILD and psoriasis.
我们遇到了患有银屑病的间质性肺疾病（ILD）患者。本病例系列的目的是研究合并银屑病和ILD患者的临床及影像学特征。
这是一项对我们机构中ILD合并银屑病患者经验的回顾性研究，数据来自西奈山医院高级肺部/间质性肺疾病项目的数据库。在447例ILD患者中，我们确定了21例（4.7%）有银屑病既往或合并诊断。临床、影像学、病理及预后数据均从我们的病历中提取。
中位年龄为66岁（范围46 - 86岁），14例（66.7%）为男性。13例（61.9%）既往或当时未接受过针对银屑病的免疫抑制治疗。2例（9.5%）最终死亡。ILD的临床诊断包括特发性肺纤维化11例（52.4%）；非特异性间质性肺炎（NSIP）2例（9.5%）；隐源性机化性肺炎2例（9.5%）；慢性过敏性肺炎2例（9.5%）；以及其他类型。影像学诊断包括普通间质性肺炎模式9例（42.9%）；NSIP模式6例（28.6%）；机化性肺炎模式4例（19.0%）；过敏性肺炎模式2例（9.5%）；以及其他类型。
我们报告了21例有银屑病既往或合并诊断的ILD病例。需要进一步的前瞻性研究来确定ILD与银屑病之间的关联。
