Villeneuve Edith, St-Pierre Anne, Haraoui Boulos
Department of Rheumatology, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
J Rheumatol. 2006 Jun;33(6):1189-93. Epub 2006 Apr 15.
Interstitial pneumonitis is a well documented, rare complication of methotrexate (MTX). We describe a patient with rheumatoid arthritis (RA) taking MTX for more than 3 years who then developed severe interstitial pneumonitis after a third infliximab infusion. Other similar cases are reviewed. Infliximab may potentiate pulmonary toxicity of MTX.
间质性肺炎是甲氨蝶呤（MTX）一种有充分文献记载的罕见并发症。我们描述了一名类风湿关节炎（RA）患者，服用MTX超过3年，在第三次输注英夫利昔单抗后发生了严重的间质性肺炎。并对其他类似病例进行了回顾。英夫利昔单抗可能会增强MTX的肺毒性。
