Adler M W, Bendotti C, Ghezzi D, Samanin R, Valzelli L
Psychopharmacologia. 1975;41(1):15-8. doi: 10.1007/BF00421299.
Although the effects of differential housing, particularly isolation, on the action of several classes of pharmacological agents have been studied, little attention has been given to this factor in regard to narcotics. The present study involves the effects of long-term social isolation on dependence to morphine produced by pellet implants in rats. When abstinence was precipitated with naloxone, isolated rats demonstrated less jumping and less diarrhea then grouped rats. No differences were found in other signs. In addition, the differences were seen both in isolates developing muricidal behavior and those not developing this behavioral pattern.
尽管已经研究了不同饲养环境，特别是隔离环境，对几类药理制剂作用的影响，但在麻醉品方面，这个因素很少受到关注。本研究涉及长期社会隔离对大鼠因植入药 pellet 产生的吗啡依赖性的影响。当用纳洛酮引发戒断反应时，与群居大鼠相比，隔离大鼠表现出更少的跳跃和腹泻。在其他体征方面未发现差异。此外，在出现杀鼠行为的隔离大鼠和未出现这种行为模式的隔离大鼠中都观察到了差异。
