Hadaway P F, Alexander B K, Coambs R B, Beyerstein B
Psychopharmacology (Berl). 1979;66(1):87-91. doi: 10.1007/BF00431995.
To determine whether opiate consumption is affected by laboratory housing, individually caged and colony rats were given a choice between water and progressively more palatable morphine-sucrose solutions. The isolated rats drank significantly more of the opiate solution, and females drank significantly more than males. In the experimental phase during which morphine-sucrose solution consumption was greatest, the isolated females drank five times as much, and the isolated males sixteen times as much morphine (mg/kg) as the colony females and males respectively.
为了确定阿片类药物的消耗是否受实验室饲养环境的影响，将单独饲养和群体饲养的大鼠置于水和口味逐渐更佳的吗啡 - 蔗糖溶液之间进行选择。单独饲养的大鼠饮用的阿片类溶液明显更多，并且雌性大鼠的饮用量显著多于雄性大鼠。在吗啡 - 蔗糖溶液消耗量最大的实验阶段，单独饲养的雌性大鼠的饮用量是群体饲养雌性大鼠的五倍，单独饲养的雄性大鼠的吗啡饮用量（毫克/千克）是群体饲养雄性大鼠的十六倍。
