Henry C, Mitropoulou V, New A S, Koenigsberg H W, Silverman J, Siever L J
Service Universitaire de Psychiatrie, Centre Hospitalier Charles Perrens, 121 rue de la Béchade, 33076, Bordeaux, France.
J Psychiatr Res. 2001 Nov-Dec;35(6):307-12. doi: 10.1016/s0022-3956(01)00038-3.
many studies have reported a high degree of comorbidity between mood disorders, among which are bipolar disorders, and borderline personality disorder and some studies have suggested that these disorders are co-transmitted in families. However, few studies have compared personality traits between these disorders to determine whether there is a dimensional overlap between the two diagnoses. The aim of this study was to compare impulsivity, affective lability and intensity in patients with borderline personality and bipolar II disorder and in subjects with neither of these diagnoses.
patients with borderline personality but without bipolar disorder (n=29), patients with bipolar II disorder without borderline personality but with other personality disorders (n=14), patients with both borderline personality and bipolar II disorder (n=12), and patients with neither borderline personality nor bipolar disorder but other personality disorders (OPD; n=93) were assessed using the Affective Lability Scale (ALS), the Affect Intensity Measure (AIM), the Buss-Durkee Hostility Inventory (BDHI) and the Barratt Impulsiveness Scale (BIS-7B).
borderline personality patients had significantly higher ALS total scores (P<0.05) and bipolar II patients tended to have higher ALS scores than patients with OPD (P<0.06). On one of the ALS subscales, the borderline patients displayed significant higher affective lability between euthymia and anger (P<0.002), whereas patients with bipolar II disorder displayed affective lability between euthymia and depression (P<0.04), or elation (P<0.01) or between depression and elation (P<0.01). A significant interaction between borderline personality and bipolar II disorder was observed for lability between anxiety and depression (P<0.01) with the ALS. High scores for impulsiveness (BISTOT, P<0.001) and hostility (BDHI, P<0.05) were obtained for borderline personality patients only and no significant interactions between diagnoses were observed. Only borderline personality patients tended to have higher affective intensity (AIM, P<0.07).
borderline personality disorder and bipolar II disorder appear to involve affective lability, which may account for the efficacy of mood stabilizers treatments in both disorders. However, our results suggest that borderline personality disorder cannot be viewed as an attenuated group of affective disorders.
许多研究报告了情绪障碍之间的高度共病性,其中包括双相情感障碍和边缘型人格障碍,并且一些研究表明这些障碍在家族中共同传递。然而,很少有研究比较这些障碍之间的人格特质,以确定这两种诊断之间是否存在维度重叠。本研究的目的是比较边缘型人格障碍患者、双相II型障碍患者以及既无这两种诊断的受试者的冲动性、情感不稳定性和强度。
使用情感不稳定性量表(ALS)、情感强度测量量表(AIM)、巴斯-杜克敌意量表(BDHI)和巴拉特冲动性量表(BIS-7B)对边缘型人格障碍但无双相情感障碍的患者(n=29)、双相II型障碍但无边缘型人格障碍但有其他人格障碍的患者(n=14)、同时患有边缘型人格障碍和双相II型障碍的患者(n=12)以及既无边缘型人格障碍也无双相情感障碍但有其他人格障碍(OPD;n=93)的患者进行评估。
边缘型人格障碍患者的ALS总分显著更高(P<0.05),双相II型障碍患者的ALS得分往往高于OPD患者(P<0.06)。在ALS的一个子量表上,边缘型人格障碍患者在心境正常与愤怒之间表现出显著更高的情感不稳定性(P<0.002),而双相II型障碍患者在心境正常与抑郁之间(P<0.04)、或在心境正常与躁狂之间(P<0.01)、或在抑郁与躁狂之间(P<0.01)表现出情感不稳定性。在焦虑与抑郁之间的情感不稳定性方面,观察到边缘型人格障碍和双相II型障碍之间存在显著交互作用(P<0.01)。仅边缘型人格障碍患者的冲动性得分较高(BISTOT,P<0.001)和敌意得分较高(BDHI,P<0.05),未观察到诊断之间的显著交互作用。仅边缘型人格障碍患者的情感强度往往更高(AIM,P<0.07)。
边缘型人格障碍和双相II型障碍似乎都涉及情感不稳定性,这可能解释了心境稳定剂治疗在这两种障碍中的疗效。然而,我们的结果表明,边缘型人格障碍不能被视为情感障碍的一个弱化组。