Schmitz F
Institute for Anatomy, Julius-Maximilians-University of Würzburg, Koellikerstrasse 6, 97070 Würzburg, Germany.
Neurosci Lett. 2001 Nov 2;313(1-2):25-8. doi: 10.1016/s0304-3940(01)02238-8.
alpha-, beta- Spectrin is ubiquitously distributed in neuronal compartments, i.e. at the plasma membrane of neuronal cell bodies, axonal and dendritic processes, pre- and postsynaptic nerve terminals and around synaptic vesicles, "Brain Res. Bull. 50 (1999) 345". Ultrastructural analyses in the rat retina using the monoclonal antibody AA6, "Hear. Res. 43 (1990) 199", against non-erythroid alpha-spectrin, alphaSPII (spectrin nomenclature according to "Blood 81 (1993) 3173"), revealed that the antibody intensively labeled the cytoplasmic face of the plasma membrane in virtually all neuronal processes. However, no significant immunolabel was observed at the presynaptic plasma membrane, around synaptic vesicles, at presynaptic densities and synaptic ribbons. Therefore, synaptic non-erythroid alpha-spectrin differs immunologically from extrasynaptic non-erythroid alpha-spectrin. This heterogeneity might contribute to the generation of distinct retinal microdomains.
α-、β-血影蛋白广泛分布于神经元各部分，即在神经元细胞体的质膜、轴突和树突、突触前和突触后神经末梢以及突触小泡周围，《脑研究通报》50 (1999) 345。使用针对非红细胞α-血影蛋白αSPII（血影蛋白命名法参照《血液》81 (1993) 3173）的单克隆抗体AA6对大鼠视网膜进行超微结构分析，《听觉研究》43 (1990) 199，结果显示该抗体几乎在所有神经元突起中都强烈标记了质膜的胞质面。然而，在突触前质膜、突触小泡周围、突触前致密区和突触带未观察到明显的免疫标记。因此，突触非红细胞α-血影蛋白在免疫上与突触外非红细胞α-血影蛋白不同。这种异质性可能有助于形成不同的视网膜微区。
