Gregoriou O, Konidaris S, Botsis D, Papadias C, Makrakis E, Creatsas G
2nd Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, 76 Vas Sophias Ave, Athens 115 28, Greece.
Maturitas. 2001 Oct 31;40(1):95-9. doi: 10.1016/s0378-5122(01)00234-1.
The aim of the present study is to evaluate the long term effects of Tibolone (Livial) on uterine myomas volume as well as on uterine arteries pulsatility index (PI) in postmenopausal women.
This study included 66 naturally menopausal women. Twenty of them (group A) had no uterine myomas; 23 of them (group B) had a single, asymptomatic, intramural or subserous myoma of a maximum diameter less or equal than 2 cm; 23 of them (group C) had a single, asymptomatic, intramural or subserous myoma of a maximum diameter between 2 and 5 cm. The volume of the myomas as well as the pulsatility index of the uterine arteries was assessed by transvaginal ultrasonography every 6 months after administration of Tibolone (2.5 mg daily).
No statistically significant difference on myomas volume was found after a 3-year period of Tibolone administration. The uterine artery basal PI was significantly higher in group A compared to that of groups B and C. After 6 months of Tibolone administration the PI in group A was significantly lower compared to the basal one whereas in groups B and C was significantly higher compared to the basal value.
Our results suggest that treating postmenopausal woman with Tibolone on a long-term basis: (a) does not increase the volume of uterine myomas and (b) has an early effect on uterine haemodynamics (decrease of PI in women without myomas and increase of PI in women with myomas).
本研究旨在评估替勃龙（利维爱）对绝经后女性子宫肌瘤体积以及子宫动脉搏动指数（PI）的长期影响。
本研究纳入66名自然绝经女性。其中20名（A组）无子宫肌瘤；23名（B组）有单个无症状肌壁间或浆膜下肌瘤，最大直径小于或等于2 cm；23名（C组）有单个无症状肌壁间或浆膜下肌瘤，最大直径在2至5 cm之间。在给予替勃龙（每日2.5 mg）后，每6个月通过经阴道超声评估肌瘤体积以及子宫动脉搏动指数。
在给予替勃龙3年期间，未发现肌瘤体积有统计学显著差异。A组子宫动脉基础PI显著高于B组和C组。给予替勃龙6个月后，A组PI与基础值相比显著降低，而B组和C组PI与基础值相比显著升高。
我们的结果表明，长期用替勃龙治疗绝经后女性：（a）不会增加子宫肌瘤体积；（b）对子宫血流动力学有早期影响（无肌瘤女性PI降低，有肌瘤女性PI升高）。
