Gutierrez J A, Norenberg M D
Arch Neurol. 1975 Feb;32(2):123-6. doi: 10.1001/archneur.1975.00490440073012.
A light microscopic study was performed during the preictal period following the administration of methionine sulfoximine (MSO) to adult rats. The principal morphologic observation was the development of Alzheimer II astrocytes in gray matter, suggesting that the metabolic abnormality induced by MSO is initially confined to the astrocyte. In view of the association of the Aizheimer II astrocyte with hyperammonemic states, the drug toxicity may be secondary to the presence of ammonia. A possible mechanism involves astrocytes in the development of seizures produced by MSO.
在成年大鼠给予蛋氨酸亚砜胺（MSO）后的发作前期进行了光镜研究。主要的形态学观察结果是灰质中出现阿尔茨海默II型星形胶质细胞，这表明MSO诱导的代谢异常最初局限于星形胶质细胞。鉴于阿尔茨海默II型星形胶质细胞与高氨血症状态相关，药物毒性可能继发于氨的存在。一种可能的机制涉及星形胶质细胞在MSO引起的癫痫发作中的作用。
