Bouillot S, Coquet M, Ferrer X, Lagueny A, Leroy J P, Vital C
Service d'Anatomie Pathologique, Hôpital Pellegrin, CHU Bordeaux, place Amélie Raba-Léon, 33076 Bordeaux Cedex, France.
Ann Pathol. 2001 Aug;21(4):334-6.
Inclusion body myositis (IBM) is a severe form of idiopathic inflammatory myopathy. A predominantly T CD8+ lymphocytic infiltrate, with focally non-necrotizing muscular fiber invasion, and rimmed-vacuoles are specific histological signs. A few cases of IBM associated with other dysimmune diseases have been reported, but only once with systemic sarcoidosis. We report three cases of muscular sarcoidosis associated with IBM. This very uncommon observation suggests that major complex of histocompatibility, soluble factors, cytokines and adhesion molecules could be involved. Our cases are a novel example of associated dysimmune diseases.
包涵体肌炎（IBM）是特发性炎性肌病的一种严重形式。主要为T CD8 +淋巴细胞浸润，伴有局灶性非坏死性肌纤维浸润，以及镶边空泡是其特异性组织学表现。已有少数IBM与其他免疫失调疾病相关的病例报道，但仅有一例与系统性结节病相关。我们报告了三例与IBM相关的肌肉结节病病例。这种非常罕见的观察结果提示，组织相容性主要复合体、可溶性因子、细胞因子和黏附分子可能参与其中。我们的病例是相关免疫失调疾病的一个新例子。
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