Layzer Robert, Lee Han Sung, Iverson Donald, Margeta Marta
Department of Neurology, Box 0114, UCSF, University of California, San Francisco, California 94143, USA.
Muscle Nerve. 2009 Sep;40(3):469-71. doi: 10.1002/mus.21377.
The pathogenic role of inflammation in inclusion body myositis (IBM) remains uncertain. A 63-year-old man developed a severe, rapidly progressive myopathy with clinical features typical of dermatomyositis (DM), but muscle pathology was typical of IBM. Treatment with prednisone and methotrexate resulted in complete remission of symptoms. Together with two similar cases reported previously, this case suggests that the inflammatory process of DM may trigger the pathologic changes of IBM.
炎症在包涵体肌炎（IBM）中的致病作用仍不明确。一名63岁男性患有一种严重的、快速进展的肌病，其临床特征为典型的皮肌炎（DM），但肌肉病理学表现为典型的IBM。泼尼松和甲氨蝶呤治疗使症状完全缓解。连同之前报道的两例类似病例，该病例提示DM的炎症过程可能引发IBM的病理改变。
