Wand A J
The Johnson Research Foundation & Department of Biochemistry & Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Nat Struct Biol. 2001 Nov;8(11):926-31. doi: 10.1038/nsb1101-926.
Recent developments in solution NMR methods have allowed for an unprecedented view of protein dynamics. Current insights into the nature of protein dynamics and their potential influence on protein structure, stability and function are reviewed. Particular emphasis is placed on the potential of fast side chain motion to report on the residual conformational entropy of proteins and how this entropy can enter into both the thermodynamic and kinetic aspects of protein function.
溶液核磁共振方法的最新进展使人们对蛋白质动力学有了前所未有的认识。本文综述了目前对蛋白质动力学本质及其对蛋白质结构、稳定性和功能潜在影响的见解。特别强调了快速侧链运动在反映蛋白质残余构象熵方面的潜力，以及这种熵如何影响蛋白质功能的热力学和动力学方面。
