Butterworth R F, Barbeau A
Can J Biochem. 1975 Mar;53(3):308-11. doi: 10.1139/o75-043.
The distribution of apomorphine following subcutaneous injection of 20 mg/kg (as the hydrochloride) was measured spectrofluorometrically in specific regions of rat brain. Measurable concentrations were found in the brain within a few minutes of injection, the drug was still detectable for at least 60 min in all regions, and maximum concentration was observed 20 min after injection. Stereotyped behavior, characteristic of apomorphine action, followed a time course parallel to accumulation of the drug in the brain.
皮下注射20mg/kg（以盐酸盐形式）阿扑吗啡后，采用荧光分光光度法测定大鼠脑特定区域中阿扑吗啡的分布。注射后几分钟内即可在脑中检测到可测量的浓度，所有区域中该药物至少60分钟内仍可检测到，注射后20分钟观察到最大浓度。阿扑吗啡作用特有的刻板行为，其时间进程与药物在脑中的蓄积平行。
