Smiałowski A, Melzacka M, Rurak A, Vetulani J
Neurosci Lett. 1979 Aug;13(3):295-9. doi: 10.1016/0304-3940(79)91509-x.
Apomorphine concentration was assayed in the caudate nucleus, hippocampus and cerebellum of rabbits injected with various doses of the drug 30 min earlier. Apomorphine accumulation was dose-dependent but uneven in the structures tested: the accumulation in the caudate nucleus being approx. 5 times higher than in cerebellum. Pretreatment with haloperidol significantly depressed the accumulation of apomorphine in the caudate nucleus and hippocampus, but not in the cerebellum. The amount of apomorphine displaceable by haloperidol was approx. 10 times higher in the caudate nucleus than in the hippocampus. The results suggest the existence of small number of apomorphine binding sites in the hippocampus.
对30分钟前注射了不同剂量药物的兔子的尾状核、海马体和小脑进行了阿扑吗啡浓度测定。阿扑吗啡的蓄积呈剂量依赖性，但在所测试的结构中并不均匀：尾状核中的蓄积量约为小脑的5倍。用氟哌啶醇预处理可显著降低尾状核和海马体中阿扑吗啡的蓄积，但对小脑无影响。氟哌啶醇可置换的阿扑吗啡量在尾状核中比在海马体中高约10倍。结果表明海马体中存在少量阿扑吗啡结合位点。
