van Rijn R R, Lequin M H, Robben S G, Hop W C, van Kuijk C
Department of Radiology, Suite D 206, University Hospital Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Pediatr Radiol. 2001 Oct;31(10):748-52. doi: 10.1007/s002470100531.
In our Paediatric Radiology Department, the Greulich and Pyle technique is used to assess skeletal age. Several authors have raised questions with regard to the applicability of this technique in a contemporary paediatric and adolescent population.
To compare skeletal age and calendar age in a healthy Dutch Caucasian population in order to test the applicability in this specific population.
For this study we enrolled 278 Dutch Caucasian boys (age range 5.0-19.5 years, mean 12.6 years) and 294 Dutch Caucasian girls (age range 5.2-19.9 years, mean 12.2 years). Radiographs of the left hand were scored according to the Greulich and Pyle atlas by two investigators.
Intra-observer coefficient of variation of duplicate assessment of skeletal age for investigator 1 (resident) was 2.4 % and for investigator 2 (radiologist) was 1.5 %. We found no significant systematic differences between the two observers regarding variability and levels of measurement, and the agreement was good. There was a strongly significant correlation between skeletal and calendar age rgirls = 0.974 and rboys = 0.979 (P < 0.001). On average, calendar age preceded skeletal age by a small amount (1.7 months in girls and 3.3 months in boys, both P < 0.001).
The reliability of the Greulich and Pyle atlas in our study corresponds well with previously reported studies. Based on our data, we conclude that the Greulich and Pyle atlas is still applicable in Dutch Caucasian children and adolescents.
在我们的儿科放射科，采用格-派（Greulich and Pyle）技术评估骨龄。几位作者对该技术在当代儿童和青少年人群中的适用性提出了疑问。
比较健康荷兰白种人群的骨龄和实际年龄，以测试该技术在这一特定人群中的适用性。
本研究纳入了278名荷兰白种男孩（年龄范围5.0 - 19.5岁，平均12.6岁）和294名荷兰白种女孩（年龄范围5.2 - 19.9岁，平均12.2岁）。两名研究人员根据格-派图谱对左手X线片进行评分。
研究者1（住院医师）对骨龄重复评估的观察者内变异系数为2.4%，研究者2（放射科医生）为1.5%。我们发现两位观察者在变异性和测量水平方面没有显著的系统差异，一致性良好。骨龄与实际年龄之间存在高度显著的相关性，女孩r = 0.974，男孩r = 0.979（P < 0.001）。平均而言，实际年龄略先于骨龄（女孩为1.7个月，男孩为3.3个月，均P < 0.001）。
我们研究中格-派图谱的可靠性与先前报道的研究结果相符。基于我们的数据，我们得出结论，格-派图谱仍适用于荷兰白种儿童和青少年。
