Goto T, Kido M A, Yamaza T, Tanaka T
Laboratory of Oral Anatomy and Cell Biology, Graduate School of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Med Electron Microsc. 2001 Jun;34(2):77-85. doi: 10.1007/s007950170001.
Substance P (SP) is an important member of the tachykinin family of neuropeptides, which work as neurotransmitters or neuromodulators. Recent advances in the analysis of SP receptors, particularly the neurokinin-1 receptors (NK1-Rs) that have high affinity for SP, have demonstrated that they are distributed not only in the cells of the neuronal or immune systems but also in peripheral cells. Therefore, the effect of SP and its cellular receptors is not limited to the nervous or immune systems, but is more extensive than previously appreciated. SP-like immunoreactive (SP-LI) axons have been localized in both bone and gingival tissue, and SP receptors are widely distributed in osteoclasts, osteoblasts, and junctional epithelial cells, as well as in neutrophils and endothelial cells. The distribution of SP-LI axons and SP receptors suggests that SP may directly modulate bone metabolism and gingival tissue functions through SP receptors.
P物质（SP）是神经肽速激肽家族的重要成员，其作为神经递质或神经调节剂发挥作用。SP受体分析的最新进展，特别是对SP具有高亲和力的神经激肽-1受体（NK1-Rs），表明它们不仅分布在神经元或免疫系统的细胞中，还分布在外周细胞中。因此，SP及其细胞受体的作用不仅限于神经或免疫系统，而是比以前认识到的更为广泛。SP样免疫反应性（SP-LI）轴突已定位在骨和牙龈组织中，SP受体广泛分布于破骨细胞、成骨细胞和结合上皮细胞以及中性粒细胞和内皮细胞中。SP-LI轴突和SP受体的分布表明，SP可能通过SP受体直接调节骨代谢和牙龈组织功能。
