Kawakami M, Kimura F
Endocrinol Jpn. 1975 Feb;22(1):43-8. doi: 10.1507/endocrj1954.22.43.
The fornix was sectioned in the frontal plane by means of a razor blade knife, and acute and chronic effects of this section on gonadotropin secretion were estimated. The 5-day cyclic rat which received the section of fornix under either anesthesia at 12:00 on the day of diestrus II showed advancement of the proestrous and estrous vaginal smears and as well as ovulatory gonadotropin release by one day. It was revealed that the primary effect was the inducement of FSH release on the day of section. The 4-day cyclic rat bearing the fornix section chronically resumed vaginal cyclicity after elapsing the diestrous period for 18 to 25 days. The rat ovulated normally and mean number of ova inoviducts was not different from that in the intact rat. However, the sectioned rat hadan higher concentrations of pituitary and serum FSH on the day of diestrus II than thatin the intact rat, and had an higher concentration of serum LH on the day of estrus. These results indicate that the hippocampus exerts the inhibitory influence on LH and FSH release and if this is eliminated the facilitatory influence dominates the brain mechanism controlling gonadotropin release, resulting in the advancement of estrous cycle (the acute effect) or the increase of gonadotropin release (the chronic effect).
用剃须刀片在额平面切断穹窿，并评估该切断对促性腺激素分泌的急性和慢性影响。在动情周期II第12点处于麻醉状态下接受穹窿切断的5天周期大鼠，动情前期和动情期阴道涂片以及排卵促性腺激素释放提前了一天。结果显示主要作用是在切断当天诱导促卵泡激素（FSH）释放。长期切断穹窿的4天周期大鼠在经历18至25天的动情间期后恢复了阴道周期。大鼠正常排卵，输卵管内卵子的平均数量与完整大鼠无异。然而，切断穹窿的大鼠在动情周期II当天垂体和血清促卵泡激素（FSH）的浓度高于完整大鼠，在动情期血清促黄体生成素（LH）的浓度更高。这些结果表明海马体对促黄体生成素（LH）和促卵泡激素（FSH）的释放具有抑制作用，如果这种抑制作用被消除，促进作用将主导控制促性腺激素释放的脑机制，导致动情周期提前（急性效应）或促性腺激素释放增加（慢性效应）。
