Saksena S K, Lau I F, Chang M C
Fertil Steril. 1975 Feb;26(2):126-30. doi: 10.1016/s0015-0282(16)40931-3.
Insertion of a Silastic-PVP implant containing 150 mug PGF2alpha into one of the uterine horns or administration of a single subcutaneous injection of 4 mug of Depo-Estradiol Cypionate (ECP) did not induce abortion in pregnant rats. However, a combined treatment with 150 mug of PGF2alpha in a Silastic-PVP implant and 4 mug of ECP induced abortion in all treated rats. Apparently, ECP stimulated endogenous production of PGF and consequently enhanced the effect of the administered 150 mug of PGF2alpha. The release of 3H-PGF2alpha from Silastic-PVP implants was faster after intrauterine or intraperitoneal than after subcutaneous insertion. The release rate of 3H-PGF2alpha from Silastic-PVP implants in vitro was comparable to that observed after subcutaneous placement of similar implants. It is suggested that administration of estrogen combined with PGF2alpha might shorten the interval between treatment with PGF2alpha and abortion. Moreover, a Silastic-PVP implant would lend itself as a better method of administration, releasing PGF2alpha locally, slowly, and continuously.
将含有150微克前列腺素F2α（PGF2α）的硅橡胶-聚乙烯吡咯烷酮（Silastic-PVP）植入物插入孕鼠的一个子宫角，或单次皮下注射4微克环戊丙酸雌二醇（ECP），均未引起孕鼠流产。然而，将含有150微克PGF2α的Silastic-PVP植入物与4微克ECP联合处理，可使所有接受处理的大鼠流产。显然，ECP刺激了PGF的内源性产生，从而增强了所给予的150微克PGF2α的作用。子宫内或腹腔内植入Silastic-PVP植入物后，3H-PGF2α的释放比皮下植入后更快。体外实验中，Silastic-PVP植入物中3H-PGF2α的释放速率与皮下植入类似植入物后观察到的释放速率相当。研究表明，雌激素与PGF2α联合给药可能会缩短PGF2α处理与流产之间的间隔时间。此外，Silastic-PVP植入物将是一种更好的给药方法，可在局部缓慢且持续地释放PGF2α。
