Lau I F, Saksena S K, Chang M C
Fertil Steril. 1975 Jan;26(1):74-9.
The action of prostaglandin F2alpha (PGF2-alpha) to induce midterm abortion in rabbits, rats, hamsters, and mice using different methods and routes of administration was studied. Administration of PGF-alpha in a Silastic-PVP implant was more effective than was the parenteral injection at the same dose levels. The efficacy of PGF2alpha was optimum when deposited locally in the uterine lumen as a Silastic-PVP implant, a condition comparable to a continuous intra-amniotic or extra-amniotic administration of PGF2alpha in women. It is possible that the insertion of a Silastic-PVP implant into the uterine lumen results in a continuous PGF2alpha release and a high local PGF2alpha concentration which minimizes such factors as dilution and the short half life displayed in the general circulation. PGF2alpha contained in a Silastic-PVP implant and inserted into the uterine lumen may effectively induce abortion with a comparatively lower dose than that necessary for parenteral routes of administration.
研究了前列腺素F2α（PGF2-α）通过不同方法和给药途径在兔、大鼠、仓鼠和小鼠中诱导中期流产的作用。在相同剂量水平下，将PGF-α植入硅橡胶-聚乙烯吡咯烷酮（Silastic-PVP）中给药比肌肉注射更有效。当作为Silastic-PVP植入物局部沉积在子宫腔内时，PGF2α的效果最佳，这种情况类似于在女性中持续羊膜内或羊膜外给药PGF2α。将Silastic-PVP植入物插入子宫腔可能会导致PGF2α持续释放和局部高浓度的PGF2α，从而将诸如稀释和在体循环中显示的短半衰期等因素降至最低。包含在Silastic-PVP植入物中并插入子宫腔的PGF2α可以用比肌肉注射所需剂量相对较低的剂量有效诱导流产。
