Eyden B, Chorneyko K A
Department of Histopathology, Christie Hospital NHS Trust, Manchester, United Kingdom.
J Submicrosc Cytol Pathol. 2001 Jan-Apr;33(1-2):157-63.
A case of intranodal myofibroblastoma with amianthoid fibres was studied by histology, immunohistochemistry and electron microscopy, in a Canadian Caucasian male presenting with an inguinal mass which appeared following a sports injury. Tumour cells were spindled and formed haphazard interlacing fascicles with intervening areas of haemorrhage. They were positive for vimentin, alpha-smooth-muscle actin and HHF35. By electron microscopy, they displayed moderate numbers of rough endoplasmic reticulum cisternae, fine actin-sized filaments in cell processes, and discrete stretches of unambiguous lamina ('external' lamina), sometimes in association with short attachment plaques. The fibronectin fibrils and fibronexus junctions characteristic of myofibroblasts were not seen. The absence of fibronexus junctions and the presence of surface features typical of smooth-muscle cells (attachment plaques with overlying lamina) suggest that this tumour is not myofibroblastic but is exhibiting a degree of smooth-muscle differentiation. The findings confirm earlier observations suggesting that some intranodal myofibroblastomas are not myofibroblastic, but show a form of smooth-muscle differentiation.
对一名患有腹股沟肿块的加拿大白人男性进行了组织学、免疫组织化学和电子显微镜检查，该肿块在运动损伤后出现，为一例伴有石棉样纤维的结内肌纤维母细胞瘤。肿瘤细胞呈梭形，形成杂乱交错的束状结构，其间有出血区域。它们对波形蛋白、α-平滑肌肌动蛋白和HHF35呈阳性。通过电子显微镜观察，它们显示出中等数量的粗面内质网池、细胞突起内有细的肌动蛋白大小的细丝，以及离散的明确的板层（“外部”板层），有时与短的附着斑相关。未见到肌纤维母细胞特有的纤连蛋白原纤维和纤维连接复合体。缺乏纤维连接复合体以及存在平滑肌细胞典型的表面特征（带有覆盖板层的附着斑）表明，该肿瘤不是肌纤维母细胞性的，而是表现出一定程度的平滑肌分化。这些发现证实了早期的观察结果，即一些结内肌纤维母细胞瘤不是肌纤维母细胞性的，而是表现出一种平滑肌分化形式。
