Semax与含脯氨酸的初级肽对止血反应调节作用的比较研究。
Comparative study of modulatory effects of Semax and primary proline-containing peptides on hemostatic reactions.
作者信息
Cherkasova K A, Lyapina L A, Ashmarin I P
机构信息
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow.
出版信息
Bull Exp Biol Med. 2001 Jul;132(1):625-6. doi: 10.1023/a:1012503606536.
Intranasal administration of Semax, peptide Pro-Gly-Pro, and a mixture of peptides Pro-Gly+Gly-Pro to rats for 5 days enhanced anticoagulant and fibrinolytic potential of the plasma (total fibrinolytic activity and plasmin and plasminogen activator activities) and decreased antiplasmin concentration. Semax and Pro-Gly-Pro decreased the weight of thrombi during experimental thrombosis.
给大鼠鼻内注射促智肽（Semax）、肽Pro-Gly-Pro以及肽Pro-Gly + Gly-Pro的混合物，持续5天，可增强血浆的抗凝和纤溶潜能（总纤溶活性、纤溶酶和纤溶酶原激活剂活性），并降低抗纤溶酶浓度。在实验性血栓形成过程中，促智肽和Pro-Gly-Pro可减轻血栓重量。
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