塞米克斯及其脯氨酰-甘氨酰-脯氨酸片段对神经元钙稳态及其在谷氨酸毒性条件下存活的影响。
Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity.
作者信息
Storozhevykh T P, Tukhbatova G R, Senilova Ya E, Pinelis V G, Andreeva L A, Myasoyedov N F
机构信息
Laboratory of Membranology, Center of Children's Health, Russian Academy of Medical Sciences, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2007 May;143(5):601-4. doi: 10.1007/s10517-007-0192-x.
Semax (100 microM) and its Pro-Gly-Pro fragment (20 and 100 microM) delayed the development of calcium dysregulation and reduction of the mitochondrial potential in cultured cerebellar granule cells under conditions of glutamate neurotoxicity. Incubation with these peptides improved neuronal survival by on average 30%. The neuroprotective effect of semax in cerebral ischemia/hypoxia can be due to improvement of mitochondrial resistance to "calcium" stress.
赛美克斯（100微摩尔）及其脯氨酰 - 甘氨酰 - 脯氨酸片段（20和100微摩尔）在谷氨酸神经毒性条件下，延缓了培养的小脑颗粒细胞中钙调节异常的发展以及线粒体电位的降低。用这些肽孵育可使神经元存活率平均提高30%。赛美克斯在脑缺血/缺氧中的神经保护作用可能归因于线粒体对“钙”应激抗性的改善。
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