Terrence C F, Wisotzkey H M, Perper J A
Neurology. 1975 Jun;25(6):594-8. doi: 10.1212/wnl.25.6.594.
Thirty-seven cases of unexpected, unexplained death in epileptic patients were recorded by the Allegheny County Coroner's Office during the years 1969 through 1973. In no case was there anatomic or chemical evidence at autopsy sufficient to explain death. All patients had a duration of epilepsy greater than a year. All but two had less than one seizure per month. Blood levels of anticonvulsants at autopsy revealed only three patients with therapeutic levels of the drugs. Almost 50 percent of the cases studied had no demonstrable anticonvulsant. It is suggested that inadequate levels of anticonvulsant drugs are a significant factor associated with unexpected, unexplained death in epileptic patients.
阿勒格尼县验尸官办公室记录了1969年至1973年间37例癫痫患者意外、不明原因死亡的病例。尸检时均未发现足以解释死亡的解剖学或化学证据。所有患者癫痫病程均超过一年。除两名患者外，所有患者每月癫痫发作次数少于一次。尸检时抗惊厥药物的血药浓度显示只有三名患者药物浓度处于治疗水平。几乎50%的研究病例未检测到可证实的抗惊厥药物。提示抗惊厥药物水平不足是癫痫患者意外、不明原因死亡的一个重要相关因素。
